UBAT@DRUGS

THIS IS ABOUT THE MECHANISM OF DRUG RESISTANCE
sbb aku tgh bace Protein synthesis inhibitors 2:ader Aminoglycosides, Macrolides, tetracycline and chloramphenicol, ade subtitle psai drug resistance ne~

# Drug target unchanged

* Resistance by exclusion
o loss of drug accumulation mechanism (decreased import)
o increased drug elimination (increases export) (e.g. multidrug resistance in cancer cells)
* Resistance by metabolism
o active drug converted to an inactive form (e.g. penicillinase, insecticide resistance)
o prodrug no longer converted to its active form (e.g. resistance to purine analogues in cancer cells)

# Alterations in drug target

* elimination of target (e.g. induction of alternative pathway)
* alteration of targets' affinity for the drug
* overproduction of target (e.g. gene amplification)
* accumulation of metabolite antagonistic to drug (e.g. PABA overproduction by pneumococci)

My heart susah nak ingat especially drug ni..cmne eh??
Ader solution x??
Mmg mantap la dor2 from pharmacology department tu..hehe
Bkn mereka je..seme la doc2 sluruh dunia nih..Thumbs up!!!